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SHPRH (SNF2 Histone Linker PHD RING Helicase) is a gene that encodes a DNA helicase involved in repairing DNA damage and maintaining genomic stability. It plays a key role in the DNA damage response by helping to repair double-strand breaks, which prevents mutations that could lead to cancer. SHPRH is recognised as a tumour suppressor, with mutations linked to increased risks of various cancers.

